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pentobarbital decreases amounts of toremifene by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe. CYP3A4 inducers maximize rate of toremifene metabolism, decreasing the regular-point out concentration in serum.pentobarbital will minimize the level or result of meloxicam by impacting hepatic enzyme CYP2C9/10 metabolism. In